3-pyridylmethyl N-[[4-[[2-amino-5-(2-thienyl)phenyl]carbamoyl]phenyl]methyl]carbamate

Histone deacetylase HDAC1 inhibitor IC50 = 6 nM, HCT-116 mouse xenograft model GI50 = 155 nM 

Chemical Formula: C25H22N4O3S

Molecular Weight: 458.5

OTAVAchemicals Catalogue Number:  7070707090

CAS Registry Number:  849233-98-3

Purity:  98%

Ref.: Bioorg. Med. Chem. Lett. ,2008, 18, 726–731

Abstract:  Selective HDAC1/2 inhibitor, exhibiting selectivity over class II HDACs 3–8. Histone deacetylases are considered promising targets for cancer epigenetic therapy

DOI: 10.1016/j.bmcl.2007.11.047