N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]-urea

inhibitor of the Hedgehog Signalling Pathway with IC₅₀ = 70 nM

OTAVAchemicals Catalogue Number: 1156359

CAS Registry Number: 330796-24-2

Purity: 97%+ (HPLC)

Ref.: Brunton, Shirley A.; Stibbard, John H. A.; Rubin, Lee L. et al. Potent Inhibitors of the Hedgehog Signaling Pathway. Journal of Medicinal Chemistry (2008), 51(5), 1108-1110

Abstract: A small family of Ph quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Prelim inary SAR studies of the urea substituent led to a nanomolar Hedgehog antago nist.

DOI: 10.1021/jm070694n

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