N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

Non-ATP-competitive mitogen-activated protein kinase kinase MEK1/2 inhibitor IC50 = 1 nMin in vitro assay and 0.43 nM in a cell-based assay

OTAVAchemicals Catalogue Number: 7070707062

CAS Registry Number: 391210-10-9

Purity: 98% (HPLC)

Ref.: Ann. Med. 2006, 38, 3, 200 – 211

Abstract: Mitogen-activated protein kinase kinase (MEK1/2) as a component of the ERK pathway represents an excellent target for the development of anticancer drugs

DOI: 10.1080/07853890600551037

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