2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid

KD for eIF4E binding is estimated of 25 µM 

OTAVAchemicals Catalogue Number: 7070707011

CAS Registry Number: 315706-13-9

Purity: 98% (HPLC)

1,2,3,4-Tetrahydro-7-isoquinolinesulfonamide

OTAVAchemicals Catalogue Number: 1183326

CAS Registry Number: 31404-61-2

Purity: 95%+ (HPLC)

N-[5-[4-chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]-acetamide

PIK93 inhibits poliovirus (PV) and coxsackievirus B3 (CVB3) viral RNA production and virus replication. PIK93 also prevents translation mediated by internal ribosome entry site (IRES).

PIK93 blocks ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi

OTAVAchemicals Catalogue Number: 7070707029

CAS Registry Number: 593960-11-3

Purity: 95%+ (HPLC)

N-(4-sulfamoylphenyl)benzamide

CAS Registry Number:  4389-07-5

Purity: 95%

N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide

Molecular Weight: 388.4706

OTAVAchemicals Catalogue Number: 7070707140

CAS Registry Number: 142880-36-2

Purity: 97% (HPLC)

N,N-diethyl-2-[(2-thienylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 

Potent inhibitor of Kinesin-like protein 1 with activity in the ATPase assay of 1.7±0.4 μM and the MPM-2 cytoblot assay of 0.48±0.13 μM.

OTAVAchemicals Catalogue Number:   7112880116

CAS Registry Number: 301321-93-7

Purity: 95%+

4-(1,3-benzothiazol-2-yl)aniline

Potential PET amyloid imaging agent with K_i values 0.037 μM.

Chemical Formula: C13H10N2S

Molecular Weight: 226.3020

OTAVAchemicals Catalogue Number:   7216513379

CAS Registry Number: 6278-73-5

Purity: 100%

Izoquinolin-1-ylamine

Potent inhibitor of endothelial nitric oxide synthase, neuronal nitric oxide synthase (this isoforms are constitutively expressed  and are  regulated by Ca²⁺ ion and calmodulin) and inducible nitric oxide synthase (this isoform which  is  induced by  exogenous or endogenous  inflammatory stimuli, notably endotoxins  (LPS)  and cytokines (IL-I  etc.),  is not regulated by Ca²⁺ ion flux) with IC₅₀ values of 10.6 μM, 50 μM  and 9.9 μM respectively.

OTAVAchemicals Catalogue Number:   1055516

CAS Registry Number: 1532-84-9

Purity: 95%

2-(4-(2-(1H-benzo[d]imidazol-2-ylthio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide

A potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 µM

OTAVAchemicals Catalogue Number: 7070707145

CAS Registry Number: 561023-90-3

Purity: 97% (HPLC)

3-Bromo-5-phenylsalicylic acid (NSC109116)

metabolism of progesterone in AKR1C1-overexpressed cells was potently inhibited by 3-bromo-5-phenylsalicylic acid, which was effective from 10 nM with an IC₅₀ value equal to 460 nM

OTAVAchemicals Catalogue Number: 7070707133

CAS Registry Number: 4906-68-7

Purity: 95%+ (HPLC)

N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yl)oxy]-2-(methylthio)phenyl]-urea

BRAF IC₅₀ = 1 nm; pERK = 610 nM; SRB GI₅₀ = 470 nM

OTAVAchemicals Catalogue Number: 7070707132

CAS Registry Number: 884339-61-1

Purity: 95%+ (HPLC)

4-Amino-N-(4-chlorophenyl)-N-methyl-benzenesulfonamide

OTAVAchemicals Catalogue Number: 7070707001

CAS Registry Number: 304913-22-2

Purity: 96%+ (HPLC)

N-(1,3-Benzodioxol-5-ylmethyl)-6-methoxy-4-quinazolinamine

Potent and specific inhibitor of cGMP-specific phosphodiesterase with IC₅₀ = 230 nM. It levates the intracellular cGMP level without causing any change in the cAMP level in isolated porcine coronary arteries and it has no effect on other PDE isozymes

OTAVAchemicals Catalogue Number: 7020540496

CAS Registry Number: 150450-42-3

Purity: 95%+ (HPLC)

5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(2-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrile

Inhibitor of IKK-e kinase IC50 = 39.8 nM, ROCK2-specific inhibitor of Rho-kinases IC50 = 40.0 nM

OTAVAchemicals Catalogue Number: 7020402324

CAS Registry Number: 862812-98-4

Purity: 99% (HPLC)

5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide

Inhibitor of Polo-like kinase 1 (PLK1) pIC50 = 6.2

OTAVAchemicals Catalogue Number: 7020402323

CAS Registry Number: 916985-21-2

Purity: 97%+ (HPLC)

1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone

OTAVAchemicals Catalogue Number: 0129720262

CAS Registry Number: 314245-33-5

Purity: 97%+ (HPLC)