2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

Selective PI3Kdelta inhibitor IC50 = 3.2 µM

Chemical Formula: C22H19N7O

Molecular Weight: 397.4

OTAVAchemicals Catalogue Number: 7070707046

CAS Registry Number: 371242-69-2

Purity: 98% (HPLC)

Ref.: J. Immunol. 2003, 170, 5, 2647 – 54

Abstract: Phosphatidylinositide 3-kinases (PI3K) delta isoforms are predominantly expressed in hematopoietic cells. PI3Kdelta inhibitors are therapeutic targets to treat rheumatoid arthritis and other inflammatory diseases.

DOI: 10.4049/jimmunol.170.5.2647

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