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The Targeted AHR Modulator Library is a curated chemical screening set designed to accelerate the discovery of novel small-molecule modulators of the aryl hydrocarbon receptor (AHR) — a ligand-dependent transcription factor with key roles in immunity, cancer, inflammation, and xenobiotic metabolism.
This unique compound library supports early-stage discovery, target validation, and therapeutic innovation by providing access to structurally diverse and computationally prioritized molecules tailored for AHR-centric research and drug development programs.
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We’re excited to introduce a powerful enhancement to your compound discovery workflow. A curated subset of OTAVA’s CHEMRIYA™ Virtual Chemical Space — comprising 1.4 billion synthetically feasible small molecules (just 2.5% of our total 55+ billion compound collection) — is now fully searchable through the AI-powered CHEESE Search platform.
This seamless integration enables researchers to explore the richness and diversity of CHEMRIYA™ using three orthogonal and precision-guided similarity search modes — each tailored to different stages of the drug discovery pipeline.
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The OTAVA GPCR Agonist Library is a computationally refined collection built to explore GPCR-privileged chemical space with high scaffold diversity and strong agonist-like physicochemical profiles.
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SuFEx (Sulfur-Fluoride Exchange) Chemistry represents the next-generation approach to covalent drug discovery, chemical biology, and synthetic chemistry. Building on the principles of click chemistry, SuFEx reactions leverage the unique S(VI)–F bond, allowing precise and high-yielding chemical transformations under mild conditions.
OTAVA, in collaboration with Melius Organics, introduces a comprehensive SuFEx Handle Fragment Library, a diverse collection of aryl fluorosulfates and sulfamoyl fluorides designed to expand the druggable proteome, enhance covalent drug development, and facilitate advanced chemical synthesis.
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