SuFEx (Sulfur-Fluoride Exchange) Chemistry represents the next-generation approach to covalent drug discovery, chemical biology, and synthetic chemistry. Building on the principles of click chemistry, SuFEx reactions leverage the unique S(VI)–F bond, allowing precise and high-yielding chemical transformations under mild conditions.

OTAVA, in collaboration with Melius Organics, introduces a comprehensive SuFEx Handle Fragment Library, a diverse collection of aryl fluorosulfates and sulfamoyl fluorides designed to expand the druggable proteome, enhance covalent drug development, and facilitate advanced chemical synthesis.