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In recent years, structured RNAs have become tractable drug targets, enabling the discovery of selective modulators for riboswitches, long noncoding RNAs, G-quadruplexes, and RNA–protein complexes.
Breakthrough advances in library design, screening methodologies, and AI-based prioritization have expanded the scope of RNA-targeted drug discovery (Kovachka et al., Nat Rev Chem 2024; Lundquist et al., SLAS Discovery 2025; Morishita, ChemMedChem 2022; Momentum Bio, 2024).
Modern RNA-focused screening now combines:
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SPR/BLI for kinetic profiling and specificity ranking,
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AI-guided virtual enrichment to prioritize compounds with high “RNA-likeness” before experimental testing (Graff et al., Chem Sci 2020; Cao et al., Nat Mach Intell 2023).
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Histone deacetylase 1 (HDAC1; also known as GON-10, RPD3, or KDAC1) is a key epigenetic regulator involved in chromatin remodeling and gene expression. Aberrant HDAC1 activity has been implicated in tumorigenesis, and it is widely recognized as a high-value target for cancer therapy due to its role in promoting oncogenic transcriptional programs.
The mechanistic target of rapamycin (mTOR; also referred to as FRAP1, RAFT1, or RAPT1) is a central serine/threonine kinase that integrates nutrient and growth factor signals to regulate cell growth, proliferation, metabolism, and autophagy. Hyperactivation of mTOR signaling is a hallmark of various malignancies, contributing to uncontrolled tumor cell survival and resistance to therapy.
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SuFEx (Sulfur-Fluoride Exchange) Chemistry represents the next-generation approach to covalent drug discovery, chemical biology, and synthetic chemistry. Building on the principles of click chemistry, SuFEx reactions leverage the unique S(VI)–F bond, allowing precise and high-yielding chemical transformations under mild conditions.
OTAVA, in collaboration with Melius Organics, introduces a comprehensive SuFEx Handle Fragment Library, a diverse collection of aryl fluorosulfates and sulfamoyl fluorides designed to expand the druggable proteome, enhance covalent drug development, and facilitate advanced chemical synthesis.
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CHEMriya™ is an ultra-large combinatorial Chemical Space developed by OTAVA to transform hit expansion, hit-to-lead optimization, and compound evolution. Designed to accelerate drug discovery, CHEMriya provides access to a vast collection of chemically diverse molecules for pharmaceutical research and computational screening.
Explore CHEMriya on BioSolveIT
Start exploring via CHEESE Search
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