 Natural Product-Like Library has been designed as a special screening library containing synthetic compounds similar to natural products.
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SuFEx (Sulfur-Fluoride Exchange) Chemistry represents the next-generation approach to covalent drug discovery, chemical biology, and synthetic chemistry. Building on the principles of click chemistry, SuFEx reactions leverage the unique S(VI)–F bond, allowing precise and high-yielding chemical transformations under mild conditions.
OTAVA, in collaboration with Melius Organics, introduces a comprehensive SuFEx Handle Fragment Library, a diverse collection of aryl fluorosulfates and sulfamoyl fluorides designed to expand the druggable proteome, enhance covalent drug development, and facilitate advanced chemical synthesis.
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CHEMriya™ is an ultra-large combinatorial Chemical Space developed by OTAVA to transform hit expansion, hit-to-lead optimization, and compound evolution. Designed to accelerate drug discovery, CHEMriya provides access to a vast collection of chemically diverse molecules for pharmaceutical research and computational screening.
Explore CHEMriya on BioSolveIT
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Tissue transglutaminase 2 (tTG2) is a multifunctional enzyme involved in extracellular matrix stabilization, cell adhesion, signal transduction, and protein crosslinking. It plays a pivotal role in various physiological processes, but its dysregulation has been implicated in multiple diseases, including celiac disease, fibrosis, cancer, and neurodegenerative disorders. Due to its involvement in disease progression, tTG2 is a prime target for drug discovery, yet the development of small-molecule inhibitors remains an underexplored frontier.
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