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The Solubility Fragment Library consists of about 957 low molecular fragments with "Rule-of-Three" compliance and assured solubility in both DMSO (200mM) and PBS buffer (1mM). The library design included diversity filtering in order to provide chemical structure variety for your fragment screening program.
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The OTAVA MolGluesLike Compounds Library is a scientifically curated collection of 2750 small molecules designed to enable the discovery and development of molecular glues — a groundbreaking modality in drug discovery that stabilizes or induces protein-protein interactions (PPIs).
These specialized compounds have the potential to redefine therapeutic strategies by targeting previously “undruggable” proteins, offering exciting opportunities in areas such as oncology, immunology, and neurodegenerative disease research.
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GLP-1R (Glucagon-like peptide-1 receptor) is a clinically validated target involved in the regulation of glucose homeostasis, insulin secretion, and appetite control. Activation of GLP-1R has proven therapeutic value in the treatment of type 2 diabetes mellitus and obesity, making the discovery of novel small-molecule agonists an important direction in modern drug discovery.
The OTAVA GLP-1R Agonists Library was developed using an AI-guided cheminformatics workflow designed to identify structurally diverse compounds with predicted agonistic activity toward GLP-1R.
The following computational approaches were employed during the library design process.
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 Our company is currently offering about 100 new quaternary ammonium salts that could be of interest to your research. All quaternary ammonium salts are in stock, and a full list of the salts in our catalog is available upon request.
Synthetic experience of Otava chemists allows to carry out custom syntheses of even more complex structures of quaternary ammonium salts at a reasonable price.
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Targeted protein degradation (TPD) has emerged as a transformative drug discovery modality, enabling the selective elimination of disease-relevant proteins through hijacking of the cell's own ubiquitin–proteasome system. At the core of modern TPD strategies are E3 ubiquitin ligases - most prominently cereblon (CRBN) and von Hippel–Lindau protein (VHL) - which serve as recruiter platforms in both bifunctional PROTACs and molecular glue degraders.
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