Enhancer of zeste homolog 2 (EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit) is a histone-lysine N-methyltransferase. This enzyme plays an important role in histone methylation and, ultimately, transcriptional repression.

Mutation or over-expression of EZH2 has been linked to many forms of cancer, including bladder, uterine, breast, prostate and renal cancers. EZH2 inhibits genes responsible for suppressing of tumor development, and blocking of it activity may slow tumor growth. Therefore, EZH2 is an attractive target for anti-cancer therapy.

Sphingosine-1-phosphate receptor 1 (S1PR1, S1P receptor 1, S1P1, endothelial differentiation gene 1, EDG1) is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 has an important role in regulating endothelial cell cytoskeletal structure, migration, vascular maturation and capillary-like network formation. Also S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking. Abnormal functioning of S1PR1 is associated with cancer and multiple sclerosis. Agonists and antagonists of this receptor may have therapeutic potential in the treatment of such diseases.