Epigenetic targets are a major new category for successful drug research. Among them the protein methyltransferases (PMTs) which have crucial roles in gene transcription are an important group of enzymes that play key parts in normal physiology and human diseases. There has been a significant increase in attention towards protein arginine methyltransferases (PRMTs) which catalyze methylation of nitrogen of specific arginine residues in proteins and impact on numerous essential biological pathways by methylating different nuclear, cytoplasmic and membrane protein substrates.

Caseinolytic protease (ClpP) found in the human mitochondria is a major member of mitochondrial protein quality control system. This serine protease removes damaged or misfolded proteins in mitochondrial matrix. It is overexpressed in a wide range of acute myeloid leukemia (AML) cases and not in normal hematopoietic precursors [1].