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 Cathepsin K (CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD) is a lysosomal cysteine protease involved in bone remodeling and resorption. It has a major role in osteoporosis and other bone-related pathologies, cancer, diabetes, obesity and atherosclerosis. Cathepsin K inhibitors show great potential in the treatment of such diseases.
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 Sphingosine-1-phosphate receptor 1 (S1PR1, S1P receptor 1, S1P1, endothelial differentiation gene 1, EDG1) is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 has an important role in regulating endothelial cell cytoskeletal structure, migration, vascular maturation and capillary-like network formation. Also S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking. Abnormal functioning of S1PR1 is associated with cancer and multiple sclerosis. Agonists and antagonists of this receptor may have therapeutic potential in the treatment of such diseases.
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 The Retinoic Acid Receptor-related Orphan Receptor-γ (RORγ, RORc, NR1F3, RORG, RZR-GAMMA, RZRG, TOR or IMD42) plays an important role in metabolism, inimmunity and circadian rhythm. Abnormal functioning of RORγ is associated with inflammatory, immune and skin diseases including psoriasis. Antagonists and inverse agonists of this receptor may have therapeutic potential in the treatment of such diseases.
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 The Renin (REN, HNFJ2) is an aspartic protease (also known as an angiotensinogenase). It participates in arterial vasoconstriction and the body's renin–angiotensin–aldosterone system (RAAS) that mediates the volume of extracellular fluid (blood plasma, lymph and interstitial fluid). Thus, it regulates the body's mean arterial blood pressure. An over-active RAAS leads to vasoconstriction and retention of sodium and water. These effects cause hypertension. Therefore, renin inhibitors can be used for the treatment of hypertension.
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 Kallikrein 6 (KLK6, hK6, Bssp, Klk7, PRSS18, PRSS9, SP59, kallikrein related peptidase 6) plays an important role in various physiological processes. Disorders of KLK6 activity are observed at cancer and neurodegenerative diseases, such as Alzheimer’s disease and multiple sclerosis. Therefore, small molecule compounds modulating kallilrein 6 activity may have a significant therapeutic potential.
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