The OTAVA Covalent Inhibitors Library is a meticulously curated collection of small-molecule covalent inhibitors, each designed to form stable, often irreversible, bonds with target proteins. These compounds feature nucleophile-sensitive functional groups that enable precise and selective inhibition, making them powerful tools in modern drug discovery.
Covalent inhibitors are widely recognized for their enhanced potency, prolonged target engagement, and unique therapeutic advantages, particularly in oncology, infectious diseases, neurodegenerative disorders, and enzyme-related conditions. By forming covalent interactions with critical amino acid residues such as cysteine, serine, lysine, and histidine, these compounds provide long-lasting inhibition that can overcome resistance mechanisms and improve drug efficacy.
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The OTAVA USP30 Targeted Library is a cutting-edge collection of 624 meticulously curated chemical compounds designed for the identification and development of inhibitors targeting ubiquitin-specific protease 30 (USP30). By leveraging advanced computational methods and adhering to modern medicinal chemistry standards, this library offers researchers a unique toolset to explore therapeutic avenues for critical diseases.
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Overview
Products & services booklet 2018
Targeting protein protein interaction (PPI) is a new challenge to current drug discovery. Due to growing interest in PPI inhibitors we represent focused compound libraries covering chemical space of PPI inhibitors.
