Otava, Ltd - synthetic organic compounds for research and drug discovery
Otava, Ltd - synthetic organic compounds for research and drug discovery
Unsymmetrical Diaryliodonium Salts

Unsymmetrical Diaryliodonium SaltsDiaryliodonium salts are well-known to transfer an aryl group to carbon and heteroatom nucleophiles, and in some cases a base is required [1]. However, transition metal catalysts and supporting ligands are not needed. Moreover, reactions conducted with diaryliodonium salts are operationally simple because they are non-toxic and are not sensitive to air or moisture. Therefore diaryliodonium salts offer an important alternative to metal-catalyzed arylation reactions. Despite these attractive characteristics, a major obstacle to their adoption in chemical synthesis and discovery chemistry has been commercial availability.

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Diversity Libraries

Diversity LibrariesIt is proved that a diverse compound library is the most successful and straightforward starting point to find new leads. Moreover, it is the best way to enhance your research compound collections by adding new substances with different chemotypes.

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OTAVA G9a Targeted Library

OTAVA G9a Targeted Library

The OTAVA G9a Targeted Library comprises 561 carefully curated small molecules aimed at modulating the activity of histone methyltransferase G9a (EHMT2)—a master regulator of transcriptional repression through histone H3 lysine 9 (H3K9) methylation. This collection provides a powerful resource for researchers exploring epigenetics-driven mechanisms in cancer, neurodegeneration, inflammation, and stem cell reprogramming.

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Halogen-Enriched Fragments

Halogen-Enriched Fragment LibraryOur Halogen-Enriched Fragment Library comprises 708 brominated fragments that can explore binding sites for favorable halogen bond interactions to identify unique binding modes that are complementary to those obtained from classical fragment-based screening.
 

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Navigate OTAVA's CHEMRIYA™ Chemical Space with AI-Powered Similarity Search

We’re excited to introduce a powerful enhancement to your compound discovery workflow. A curated subset of OTAVA’s CHEMRIYA™ Virtual Chemical Space — comprising 1.4 billion synthetically feasible small molecules (just 2.5% of our total 55+ billion compound collection) — is now fully searchable through the AI-powered CHEESE Search platform.

This seamless integration enables researchers to explore the richness and diversity of CHEMRIYA™ using three orthogonal and precision-guided similarity search modes — each tailored to different stages of the drug discovery pipeline.

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