RNA-dependent RNA polymerase (RdRP, RDR or RNA replicase) is an enzyme that catalyzes the replication of RNA from an RNA template. RdRPs play a vital role in the growth of RNA viruses and are important targets for antiviral drug development.

Catechol O‑Methyl Transferase (COMT, HEL-S-98n) degrades catecholamines, catecholestrogens and various drugs having a catechol structure. Mutation of COMT is associated with obsessive-compulsive disorder in men, anxiety phenotypes in women, schizophrenia and other. Developing of the COMT inhibitors is a promising area of neuropsychiatric research. Also catechol‐O‐methyltransferase inhibitors are used as adjuvants to the levodopa/AADC inhibitor therapy for Parkinson's disease treatment.