Otava, Ltd - synthetic organic compounds for research and drug discovery
Otava, Ltd - synthetic organic compounds for research and drug discovery
Solubility Fragment Library

Solubility Fragment Library

The Solubility Fragment Library consists of about 957 low molecular fragments with "Rule-of-Three" compliance and assured solubility in both DMSO (200mM) and PBS buffer (1mM). The library design included diversity filtering in order to provide chemical structure variety for your fragment screening program.

 

 

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Quaternary Ammonium Salts

Quaternary ammonium saltsOur company is currently offering about 100 new quaternary ammonium salts that could be of interest to your research. All quaternary ammonium salts are in stock, and a full list of the salts in our catalog is available upon request.

Synthetic experience of Otava chemists allows to carry out custom syntheses of even more complex structures of quaternary ammonium salts at a reasonable price.

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Unsymmetrical Diaryliodonium Salts

Unsymmetrical Diaryliodonium SaltsDiaryliodonium salts are well-known to transfer an aryl group to carbon and heteroatom nucleophiles, and in some cases a base is required [1]. However, transition metal catalysts and supporting ligands are not needed. Moreover, reactions conducted with diaryliodonium salts are operationally simple because they are non-toxic and are not sensitive to air or moisture. Therefore diaryliodonium salts offer an important alternative to metal-catalyzed arylation reactions. Despite these attractive characteristics, a major obstacle to their adoption in chemical synthesis and discovery chemistry has been commercial availability.

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SARS-CoV-2 Targeted Libraries

SARS-CoV-2 Targeted LibrariesThe pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious global concern for public health with thousands of fatalities. Today, no specific drugs are available to treat this disease. Thus, there remains an urgent need for the development of specific antiviral therapeutics toward SARS-CoV-2.

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Viral RNA-dependent RNA Polymerases Targeted Library

Viral RdRps Targeted LibraryRNA-dependent RNA polymerase (RdRP, RDR or RNA replicase) is an enzyme that catalyzes the replication of RNA from an RNA template. RdRPs play a vital role in the growth of RNA viruses and are important targets for antiviral drug development.

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