Otava, Ltd - synthetic organic compounds for research and drug discovery
Otava, Ltd - synthetic organic compounds for research and drug discovery
Solubility Fragment Library

Solubility Fragment Library

The Solubility Fragment Library consists of about 957 low molecular fragments with "Rule-of-Three" compliance and assured solubility in both DMSO (200mM) and PBS buffer (1mM). The library design included diversity filtering in order to provide chemical structure variety for your fragment screening program.

 

 

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OTAVA MolGluesLike Compounds Library

OTAVA MolGluesLike Compounds Library

The OTAVA MolGluesLike Compounds Library is a scientifically curated collection of 2750 small molecules designed to enable the discovery and development of molecular glues — a groundbreaking modality in drug discovery that stabilizes or induces protein-protein interactions (PPIs).

These specialized compounds have the potential to redefine therapeutic strategies by targeting previously “undruggable” proteins, offering exciting opportunities in areas such as oncology, immunology, and neurodegenerative disease research.


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Navigate OTAVA's CHEMRIYA™ Chemical Space with AI-Powered Similarity Search

We’re excited to introduce a powerful enhancement to your compound discovery workflow. A curated subset of OTAVA’s CHEMRIYA™ Virtual Chemical Space — comprising 1.4 billion synthetically feasible small molecules (just 2.5% of our total 55+ billion compound collection) — is now fully searchable through the AI-powered CHEESE Search platform.

This seamless integration enables researchers to explore the richness and diversity of CHEMRIYA™ using three orthogonal and precision-guided similarity search modes — each tailored to different stages of the drug discovery pipeline.

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Quaternary Ammonium Salts

Quaternary ammonium saltsOur company is currently offering about 100 new quaternary ammonium salts that could be of interest to your research. All quaternary ammonium salts are in stock, and a full list of the salts in our catalog is available upon request.

Synthetic experience of Otava chemists allows to carry out custom syntheses of even more complex structures of quaternary ammonium salts at a reasonable price.

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AI-Optimized RNA-Binding Library

RNA Targeted Library

In recent years, structured RNAs have become tractable drug targets, enabling the discovery of selective modulators for riboswitches, long noncoding RNAs, G-quadruplexes, and RNA–protein complexes.
Breakthrough advances in library design, screening methodologies, and AI-based prioritization have expanded the scope of RNA-targeted drug discovery (Kovachka et al., Nat Rev Chem 2024; Lundquist et al., SLAS Discovery 2025; Morishita, ChemMedChem 2022; Momentum Bio, 2024).
Modern RNA-focused screening now combines:

  • Affinity Selection–Mass Spectrometry (AS-MS) for label-free, solution-phase discovery,

  • SPR/BLI for kinetic profiling and specificity ranking,

  • AI-guided virtual enrichment to prioritize compounds with high “RNA-likeness” before experimental testing (Graff et al., Chem Sci 2020; Cao et al., Nat Mach Intell 2023).

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