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The Solubility Fragment Library consists of about 957 low molecular fragments with "Rule-of-Three" compliance and assured solubility in both DMSO (200mM) and PBS buffer (1mM). The library design included diversity filtering in order to provide chemical structure variety for your fragment screening program.
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The OTAVA MolGluesLike Compounds Library is a scientifically curated collection of 871 small molecules designed to enable the discovery and development of molecular glues — a groundbreaking modality in drug discovery that stabilizes or induces protein-protein interactions (PPIs).
These specialized compounds have the potential to redefine therapeutic strategies by targeting previously “undruggable” proteins, offering exciting opportunities in areas such as oncology, immunology, and neurodegenerative disease research.
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Histone deacetylase 1 (HDAC1; also known as GON-10, RPD3, or KDAC1) is a key epigenetic regulator involved in chromatin remodeling and gene expression. Aberrant HDAC1 activity has been implicated in tumorigenesis, and it is widely recognized as a high-value target for cancer therapy due to its role in promoting oncogenic transcriptional programs.
The mechanistic target of rapamycin (mTOR; also referred to as FRAP1, RAFT1, or RAPT1) is a central serine/threonine kinase that integrates nutrient and growth factor signals to regulate cell growth, proliferation, metabolism, and autophagy. Hyperactivation of mTOR signaling is a hallmark of various malignancies, contributing to uncontrolled tumor cell survival and resistance to therapy.
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 Our company is currently offering about 100 new quaternary ammonium salts that could be of interest to your research. All quaternary ammonium salts are in stock, and a full list of the salts in our catalog is available upon request.
Synthetic experience of Otava chemists allows to carry out custom syntheses of even more complex structures of quaternary ammonium salts at a reasonable price.
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 Diaryliodonium salts are well-known to transfer an aryl group to carbon and heteroatom nucleophiles, and in some cases a base is required [1]. However, transition metal catalysts and supporting ligands are not needed. Moreover, reactions conducted with diaryliodonium salts are operationally simple because they are non-toxic and are not sensitive to air or moisture. Therefore diaryliodonium salts offer an important alternative to metal-catalyzed arylation reactions. Despite these attractive characteristics, a major obstacle to their adoption in chemical synthesis and discovery chemistry has been commercial availability.
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